A computational geometry approach for modeling neuronal fiber pathways

S Shailja, Angela Zhang, BS Manjunath


We propose a novel and efficient algorithm to model high-level topological structures of neuronal fibers. Tractography constructs complex neuronal fibers in three dimensions that exhibit the geometry of white matter pathways in the brain. However, most tractography analysis methods are time consuming and intractable. We develop a computational geometry-based tractography representation that aims to simplify the connectivity of white matter fibers. Given the trajectories of neuronal fiber pathways, we model the evolution of trajectories that encodes geometrically significant events and calculate their point correspondence in the 3D brain space.

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S Shailja, Angela Zhang, BS Manjunath,
Sep. 2021.